Tetrahydrocannabinolic Acid, a Genuine Substance of Tetrahydrocannabinol
نویسندگان
چکیده
منابع مشابه
Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana.
Tetrahydrocannabinol (THC), the psychoactive component of marijuana, is now regarded as a promising medicine because this cannabinoid has been shown to exert a variety of therapeutic activities. It has been demonstrated that THC is generated from the acidic precursor, tetrahydrocannabinolic acid (THCA) by nonenzymatic decarboxylation, and that THCA is biosynthesized by THCA synthase, which cata...
متن کاملCannabis – review of the issues related to determination of the total content of delta-9-tetrahydrocannabinol (D-9-THC) and delta 9-tetrahydrocannabinolic acid (D-9-THCA-A)
practices, then in medicine and textile industry, and over the last few decades they have become the world’s most popular and widespread drug drug. The history of cannabis consumption goes back several thousand years when it originated in Asia. The first references to cannabis can be found in Chinese and Indian writings such as Vedian hymns and Indian religious songs, dated back to the first mi...
متن کاملAffinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two
Introduction:Cannabis biosynthesizes Δ9-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ9-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of THCA-A, but its clinical application may be hampered by instability. THCA-A lacks cannabimimetic effects; we hypothesize that it has little binding affinity at cannabinoid receptor 1 (CB1). Materials and Method...
متن کاملCan You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of Δ9-Tetrahydrocannabinolic Acid A
Δ9-tetrahydrocannabinolic acid A (THCA-A) is the acidic precursor of Δ9-tetrahydrocannabinol (THC), the main psychoactive compound found in Cannabis sativa. THCA-A is biosynthesized and accumulated in glandular trichomes present on flowers and leaves, where it serves protective functions and can represent up to 90% of the total THC contained in the plant. THCA-A slowly decarboxylates to form TH...
متن کاملEnrichment and identification of Δ9-Tetrahydrocannabinolic acid synthase from Pichia pastoris culture supernatants
This data article refers to the report Δ(9)-Tetrahydrocannabinolic acid synthase (THCAS) production in Pichia pastoris enables chemical synthesis of cannabinoids (Lange et. al. 2015) [2]. THCAS was produced on a 2 L lab scale using recombinant P. pastoris KM71 KE1. Enrichment of THCAS as a technically pure enzyme was realized using dialysis and cationic exchange chromatography. nLC-ESI-MS/MS an...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1967
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.15.1075